VKORC1 is the molecular target of warfarin. Genetic variations determine your vitamin K recycling rate and directly affect anticoagulation requirements.
High Sensitivity
Drug
Warfarin
Effect
Increased sensitivity → bleeding risk
Recommendation
ADJUST. Lower dose. Frequent INR monitoring.
CPIC Guideline
CPIC Level A
FDA Label
FDA recommends PGx-guided dosing
Clinical Action: These recommendations are based on CPIC guidelines and FDA labeling. Discuss results with your healthcare provider or genetic counselor to determine appropriate treatment adjustments.
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