Gene Details

SLCO1B1

SLCO1B1 transports statins into liver cells for metabolism. Variants reduce statin clearance, increasing myopathy risk at standard doses.

Affected Medications (2)

Atorvastatin

Simvastatin

Variants & Recommendations

521T>C, 388A>G (reduced transporter activity)

Reduced Transporter

STANDARD

Drug

Atorvastatin

Effect

Moderately increased plasma levels

Recommendation

STANDARD. Monitor for myopathy symptoms.

CPIC Guideline

CPIC Level B

FDA Label

Increased levels in carriers

521T>C, 388A>G (reduced transporter activity)

Reduced/Poor Transporter

AVOID

ADJUST DOSE

Drug

Simvastatin

Effect

Increased statin levels → myopathy/rhabdomyolysis risk

Recommendation

ADJUST. Avoid >20mg daily; consider pravastatin.

CPIC Guideline

CPIC Level A

FDA Label

Increased myopathy risk

Clinical Action: These recommendations are based on CPIC guidelines and FDA labeling. Discuss results with your healthcare provider or genetic counselor to determine appropriate treatment adjustments.

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