HLA-B*5701 is a genetic marker strongly associated with abacavir (an HIV drug) hypersensitivity. Testing is recommended before starting abacavir.
Present
Drug
Abacavir
Effect
Severe hypersensitivity reaction (fever, rash, GI symptoms)
Recommendation
CONTRAINDICATED.
CPIC Guideline
CPIC Level A
FDA Label
Black box warning: test before use
Clinical Action: These recommendations are based on CPIC guidelines and FDA labeling. Discuss results with your healthcare provider or genetic counselor to determine appropriate treatment adjustments.
Know your HLA-B*5701 status? Get a personalized medication safety report.
Generate My Report